MORNING SESSION
8:30 - 10:30 AM
Anachem Award Session
Chair: Kendra Reid Evans, Chemisty Dept, UDMercy
Room 3
: Polyionsensitive Membrane Electrodes: New Applications, New Designs,
and Revisiting the Origin of Potentiometric Response Mark E. Meyerhoff,
Andrea Bell, Kebede Gemene, Lajos Höfler, and Lin Wang, Department of
Chemistry, University of Michigan, Ann Arbor, MI
Chemical and Biosensors and their Impacts on our Lives, Xiangqun Zeng,
Department of Chemistry, Oakland University, Rochester, MI
Functionalized Surface as Template for in situ Generation of Two-dimensional
Nanoparticle Assemblies Krisanu Bandyopadhyay, Thomas Chase, Amy Bondy,
and Rachel Wallen, Department of Natural Sciences, University of
Michigan-Dearborn, Dearborn, MI
In-situ SERS Analyses of the Structural and Surface Chemical Properties
of Electrodeposited Semiconductor Thin Films, Junsi Gu, Azhar Carim,
and Stephen Maldonado,, Deptt of Chemistry, University of Michigan, Ann Arbor,
MI
Mass Spectrometry
Chair :Michael Ford
Rom 1
: Higher levels of protein oxidation in liver of long-lived Snell dwarf
mice, Nicholas Niemuth, Richard Miller, and Ursula Jakob, Program in
Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI
:Solvent Assisted Inlet Ionization Mass Spectrometry of Biological
Samples, Beixi Wang and Sarah Trimpin, Wayne State University, Department
of Chemistry, Detroit, MI
Digestion-Resistant Peptides: Detection and Identification of Survivors
using Liquid Chromatography/Time-of-Flight Mass Spectrometry, Siobhan
Shay1 and A. Daniel Jones1,2, 1Department of Chemistry and 2Department of
Biochemistry and Molecular Biology, Michigan State University, East Lansing,
MI
Quantitative Lipidome Analysis of Colorectal Cancer Cells using Ultra-High
Resolution Mass Spectrometry, Cassie Patterson, 1 Sichang Liu1 and Gavin
E. Reid1,2, 1Department of Chemistry. 2Department of Biochemistry and Molecular
Biology Michigan State University, East Lansing, MI
Advances Towards Bio-Solar Energy: Utilizing Microbes in the Development
of a Renewable and Sustainable Biofuel Alternative, Eli Benchell Eisman1,
Jennifer J. Gehret1, Dr. Liangcai Gu1, William H. Gerwick2, Peter Wipf3,
Janet L. Smith1, David H. Sherman1, 1Departments of Chemical Biology, Biological
Chemistry and Medicinal Chemistry, University of Michigan, Ann Arbor, MI,
2Scripps Institution of Oceanography, University of California at San Diego,
La Jolla, CA, 3Department of Chemistry, University of Pittsburgh, Pittsburgh,
PA
Profiling of Glutathione Conjugates and other Metabolites of Arabidopsis
Glutathione S-Transferase Knockout Mutants using LC/MS and Collision Induced
Dissociation , Jiangyin BaoÆ and A. Daniel Jones1,2 1Department
of Chemistry and 2Department of Biochemistry and Molecular Biology, Michigan
State University, East Lansing, MI Yu Chen and Mary T. Rodgers*, Department
of Chemistry, Wayne State University, Detroit, MI
Explosive Chemicals Detection with Ionic Liquids Coated QCM, Min Guo
and Xiangqun Zeng*, Department of Chemistry, Oakland University, Rochester,
MI
Fabrication and Characterization of Boron-doped Diamond Microelectrode
Arrays, Leigh Ann Jordan1, Michael W. Varney2, Marion France3, Matt Fhaner1,
James J. Galligan3,4, Dean Alsum2 and Greg M. Swain1,3*, 1Department of
Chemistry, 2Department of Electrical and Computer Engineering, 3Neuroscience
Program, and 4Department of Pharmacology and Toxicology, Michigan State
University, East Lansing, MI
Simultaneous Detection of Dopamine and Adenosine using a Boron-doped Diamond
Electrode, Johnna A. Birbeck and Tiffany A. Mathews*, Department of
Chemistry, Wayne State University, Detroit, MI, Matthew Fhaner1, James Galligan2
and Greg Swain1,2*, 1Department of Chemistry and 2Department of Pharmacology
and Toxicology Michigan State University, East Lansing, MI
Immobilization of HER2 Mimotope-derived Synthetic Peptide on Au and its
Potential Application for Detection of Herceptin in Human Serum by
QCM,Yuqin Shang1, Pankaj R. Sigh1, Mohammad M. Chisti2, Ray Mernaugh3,
and Xiangqun Zeng1*, 1Department of Chemistry, Oakland University, Rochester,
MI; 2Department of Hematology and Oncology, William
Microfluidic Control of Oxygen Concentration in Flowing Erythrocyte Solutions
, Stephen T. Halpin, William Wichert, and Dana M. Spence, Department
of Chemistry, Michigan State University, East Lansing, MI
Characterizing Organic Colorants in a 15th Century Iranian Timurid Qur'an
by Direct Analysis in Real Time Time-of-Flight Mass Spectrometry, Christina
Varney1, Ruth Ann Armitage1, and Cathy Selvius DeRoo2, 1Chemistry Department,
Eastern Michigan University, Ypsilanti, MI, 2Conservation Department, Detroit
Institute of Arts, Detroit, MI
AM Workshop::LC/MS 101, PART I
Sue D’Antonio
Sheher Mohsin
Agilent Corporation
Room 2
Abstract
The morning session will cover an introduction to LC/MS techniques, as well
as, types of atmospheric ionization. We will discuss the utility of nominal
vs accurate mass measurements and compare information obtained from MS and
MSMS. Strategies for making LC methods more mass spec "friendly" will be
explored, as will creating and moving ions, mass selection and coupling MS
to HPLC.
Who Will Benefit
Anyone wanting to learn more about LC/MS in order to keep up to date on newer
methodologies, to review basic principles, to see how it could be utilized
in their laboratories, or wishing to review basic principles will benefit
from this session. In particular, these workshops target beginner to intermediate
level users.
Bios
The workshop instructors will be Sue D’Antonio and Sheher Mohsin. Both speakers
are Applications Engineers with industrial experience before joining Agilent.
Sue received her BS in Chemistry from the Illinois Institute of Technology
and her BS in Mathematics from DePaul University. LC/MS, HPLC and LC are
among her areas of technical specialization. Sheher received her Ph. D. from
the University of Illinois in Physical Chemistry. Among her areas of expertise
are LC/MS, LC/MS/MS, GC/MS and High Resolution MS.
COFFEE BREAK
10:30 - 11:30 AM Exhibit Hall
PLENARY LECTURE
Marc D. Porter
Abstract
Room 3
Nanoscience Strategies for the Design and Ultra Sensitive
Readout of Dense Immunodiagnostic Platforms
Departments of Chemistry, Chemical Engineering,
Bioengineering, and Pathology
NanoInstitute of Utah, Salt Lake City, UT 84108
The drive for early disease detection, the growing threat ofbioterrorism,
and a vast range of other innovations across biotechnology have markedly
amplified the demand for ultra sensitive, high-speed diagnostic tests. This
presentation will describe efforts to develop platforms and readout methodologies
that potentially address these needs by coupling nanometric-labeling concepts
with surface enhanced Raman scattering and giant magnetoresistance readout
methodologies. Strategies will be detailed for both the fabrication and readout
of chip-scale platforms that can be used with each readout modality, probing
fundamental dictates for optimal performance. Examples will focus on the
use of protein arrays as platforms targeted for immunoassays for the rapid,
ultra-low level detection of cancer markers and viral pathogens. Challenges
related to sensitivity, speed, and nonspecific adsorption, and fluid manipulation
will be discussed.
LUNCH
12:30 - 1:30 PM
AFTERNOON
SESSION
Academic Research
Yu Chen and Mary T. Rodgers*,
Department of Chemistry, Wayne State University, Detroit, MI
Room 1
: Explosive Chemicals Detection with Ionic Liquids Coated QCM, Min
Guo and Xiangqun Zeng*, Department of Chemistry, Oakland University, Rochester,
MI, Leigh Ann Jordan1, Michael W. Varney2, Marion France3, Matt Fhaner1,
James J. Galligan3,4, Dean Alsum2 and Greg M. Swain1,3*, 1Department of
Chemistry, 2Department of Electrical and Computer Engineering, 3Neuroscience
Program, and 4Department of Pharmacology and Toxicology, Michigan State
University, East Lansing, MI
Simultaneous Detection of Dopamine and Adenosine using a Boron-doped Diamond
Electrode, Johnna A. Birbeck and Tiffany A. Mathews*, Department of
Chemistry, Wayne State University, Detroit, MI
: Electrochemical Measurements of Chromaffin Cell Secretion in DOCA-salt
Hypertension Matthew Fhaner1, James Galligan2 and Greg Swain1,2*, 1Department
of Chemistry and 2Department of Pharmacology and Toxicology Michigan State
University, East Lansing, MI
Immobilization of HER2 Mimotope-derived Synthetic Peptide on Au and its
Potential Application for Detection of Herceptin in Human Serum by QCMYuqin
Shang1, Pankaj R. Sigh1, Mohammad M. Chisti2, Ray Mernaugh3, and Xiangqun
Zeng1*, 1Department of Chemistry, Oakland University, Rochester, MI; 2Department
of Hematology and Oncology, William Wichert, and Dana M. Spence, Department
of Chemistry, Michigan State University, East Lansing, MI
New Developments in High Speed
and Efficient Analytical Techniques
Chair: Ling Bei, EMD Millipore
Room 3
Smaller Particles, Higher Pressures and Lower Dispersion:
The LC Revolution Seven Years On, Author: Jeff BieszkimWaters Corp
The seminar will begin with an overview of the science and technology of
sub-2um LC. The performance envelope for modern LC separations will be explored
with a focus on continuing developments in chemistry, hardware and software.
The crucial role of the sub-2um particle and the equally vital contribution
of instrument design will be highlighted.
Ultra-High Performance without Ultra-High Pressure,
with Monolithic Silica HPLC Columns, Author: Ling Bei, EMD Millipore
Monolithic Silica HPLC columns have become valuable tools in analytical research,
development labs, and quality control labs. They have proven their excellent
suitability as the unique "single particle" logical alternative to particulate
packed columns for very fast and complex separations with much less backpressure.
A new generation of Chromolith® silica monoliths has now been developed
that gives the performance of modern 2um particulate columns (even core-shell)
but with much lower pressures typically seen in 5um particle packed columns.
It frees chromatographers from the traditional restrictions of packed columns
on flow rate and solvent choice, even on standard HPLCs. You get higher
consistency of results throughout much longer lifetimes, even with less sample
prep. Comparison of overall performance and separation efficiencies will
be discussed.
Innovations in LCMS, Hayley Crowe & Nonie Danna;
Presenting Author: Nonie Dannam, Perkin Elmer
With today's ever more complex and demanding lab workflows, quality of data
is everything. This presentation will examine the functional options, differences
and applications of both single quad and TOF (time of flight) mass spectrometry
along with the Flexar HPLC front end. The SQ 300 MS features a revolutionary
interchangeable probe and unique multi stage ion path for exceptional sensitivity
while maintaining long term efficiency and reliability. The AxION 2 TOF MS
has ultra-fast acquisition rate matching UHPLC high resolution LC for exact
mass identification. Revolutionary APCI, ESI and a DSA (direct sample analysis)
sources are just the beginning of the new technologies from Perkin Elmer.
New innovations in software packages include solutions for dedicated single
or new innovations in software packages include solutions for dedicated single
or multiple target analysis (AxION Solo) and zero footprint open access solutions
(AxION eDoor). These technologies allow for the most efficient & optimized
laboratory solution.
New Columns and Technologies for Fast and Efficiend Analytical
Methods
PM Workshop
LC/MS 101, Part II
Paul Winkler, ABSciex Corporation
Abstract
The afternoon LC/MS session will provide data for selected applications including
small molecules, peptides and proteins. Strategies for developing robust
methods and method troubleshooting will be discussed. In addition, common
instrumental maintenance practices will be discussed.
Who Will Benefit
Anyone who is currently developing LC/MS methods and is interested in improving
their knowledge of method development strategies, method troubleshooting
practices and good LC/MS practices will benefit from this course.
Bios
Paul is a Field Applications Chemist for AB Sciex. He received his Ph.D in
Analytical Chemistry from the Georgia Institute of Technology. He has acquired
practical experience working at DOW Chemical, DOE and GEL Analytics before
joining ABSciex. His specialties include LC/MS/MS, GC/MS and High Resolution
MS using sector and TOF instruments. He has expertise in GMP Pharmaceutical
Chemistry, Environmental Chemistry and GLP Bioanalytical Chemistry.
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POSTER/MIXER SESSION
Poster Session and Wine and Cheese Reception in the Exhibit Hall
following the oral presentations
Phosphoproteomic Analysis by Quadruple Ion Trap and Fourier Transform
Ion Cyclotron Resonance Mass Spectrometry Techniques,Zhe Jiang and Mary
T. Rodgers*, Department of Chemistry, Wayne State University, Detroit, MI
The Influence of Methylation on the Fragmentation Behavior of Noncovalent
RNA Complexes, Fadia Cudry and Mary T. Rodgers* Department of Chemistry,
Wayne State University, Detroit, MI
Theoretical and Experimental Studies of Noncovalent Metal-Ligand Interactions:
Applications to Divalent Transition Metals with N-donor Ligands, Holliness
Nose and Mary T. Rodgers* Department of Chemistry, Wayne State University,
Detroit, MI
Structures and Collision-Induced Dissociation Pathways of Protonated
2'-Deoxynucleoside-5'-Monophosphates Investigated by Guided Ion Beam Tandem
Mass Spectrometry and Theoretical Calculations, Ranran Wu, Yuan-wei Nei,
Yu Chen and Mary T. Rodgers*, Department of Chemistry, Wayne State University,
Detroit, MI
Energy dispersive X-ray fluorescence study of the elemental composition
of a variety of patent medicines and nostrums archived at the Henry Ford
Museum, Andrew Diefenbach1, Danielle Garshott1, Elizabeth MacDonald1,
Thomas Sanday1, Mary Fahey2, and Mark A. Benvenuto1*, 1Department of Chemistry
and Biochemistry, University of Detroit Mercy, Detroit, MI, 2The Henry Ford,
Dearborn, MI
Examination of a series of copper-based coins of the Kushan Empire via
energy dispersive X-ray fluorescence spectroscopym Andrew Diefenbach,
Nicholas Stroeters, and Mark A. Benvenuto*, Department of Chemistry and
Biochemistry, University of Detroit Mercy, Detroit, MI
Alkali Metal Cation - Cyclen Complexes: Effects of Alkali Metal Cation
Size on the Structure and Binding Energy, Calvin Austin and Mary T. Rodgers*,
Department of Chemistry, Wayne State University, Detroit, MI
Proton Affinities of Modified Cytosines and Hydrogen Bond Stabilization
Energies of Their Proton Bound Homo- and Hetero-Dimers, Bo Yang and Mary
T. Rodgers*, Department of Chemistry, Wayne State University, Detroit, MI
Stabilization of DNA Mononucleotides Investigated by IRMPD Action Spectroscopy
and Electronic Structure Calculations, Yuan-wei Nei1, Ranran Wu1, Nuwan
Hallowita1, Jeffrey D. Steill2, Jos Oomens2, and Mary T. Rodgers1*, 1Department
of Chemistry, Wayne State University, Detroit, MI, 2FOM Institute for Plasma
Physics "Rijnhuizen", Nieuwegein, The Netherlands
Derivatization of Short-Chain Fatty Acids (SCFA) Using 1-Pyrenyl-Diazomethane
(PDAM) on Polyacrylate, Mary Beth Kalvaitis, Heather Holmes, Dept of
Chemistry, Eastern Michigan University, Ypsilanti, MI
Bioaccumulation Studies of Zinc in Shrimp Tissue Samples using Flame Atomic
Absorption Spectroscopy, Jessica Trouten1, Patricia Walworth1, Michael
Leonard1, Lisa Cocoo2, Gregory Grabowski2, and Katherine C. Lanigan*, 1Department
of Chemistry and Biochemistry, 2Department of Biology, University of Detroit
Mercy, Detroit, MI
Development of an Automated Sampling and Injection System for Continuous
Liquid Chromatography-Mass Spectrometry-Based Hormone Detection, Lina
Basal, Alyssa V. Colbert, Joshua J. Eby, Braden, D. Iveson, Enas Karim, David
C. Moore, and Kendra R. Evans*, Department of Chemistry and Biochemistry,
University of Detroit Mercy, Detroit, MI
Statistical Comparison of EPA Methods 300.1 and 302 for Determination
of Low Level Bromate Virginia Burkel, NSF International, Ann Arbor, MI
Raman Spectroscopic Analysis of in vitro Bone Infection Models , ,Karen
Flannagan1, Karen Esmonde-White2, Michael Morris1, 1Department of Chemistry,
2Department of Internal Medicine, University of Michigan, Ann Arbor, MI
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